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Matthias Schwab Selected Research

Cytochrome P-450 CYP2D6 (CYP2D6)

3/2022(Z)-Endoxifen and Early Recurrence of Breast Cancer: An Explorative Analysis in a Prospective Brazilian Study.
5/2021Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups.
1/2021CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.
1/2021Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins.
1/2020The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer.
1/2020Obesity Alters Endoxifen Plasma Levels in Young Breast Cancer Patients: A Pharmacometric Simulation Approach.
1/2019Clinical Trial: CYP2D6 Related Dose Escalation of Tamoxifen in Breast Cancer Patients With Iranian Ethnic Background Resulted in Increased Concentrations of Tamoxifen and Its Metabolites.
1/2018Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
1/2017Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen.
8/2014CYP2D6 genotyping and tamoxifen in the treatment of post-menopausal breast cancer - a reply.
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Matthias Schwab Research Topics

Disease

53Neoplasms (Cancer)
12/2022 - 07/2002
40Breast Neoplasms (Breast Cancer)
06/2022 - 08/2006
23Drug-Related Side Effects and Adverse Reactions
11/2021 - 08/2002
19Crohn Disease (Crohn's Disease)
09/2014 - 09/2004
16Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
08/2021 - 08/2002
15Inflammation (Inflammations)
12/2020 - 12/2005
9Coronary Artery Disease (Coronary Atherosclerosis)
05/2022 - 09/2008
9Renal Cell Carcinoma (Grawitz Tumor)
03/2022 - 10/2015
8Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2021 - 01/2005
8Acute Coronary Syndrome
11/2020 - 09/2008
7Colorectal Neoplasms (Colorectal Cancer)
12/2022 - 07/2005
7Neoplasm Metastasis (Metastasis)
02/2022 - 08/2006
7Infections
01/2022 - 01/2009
7Body Weight (Weight, Body)
01/2020 - 02/2003
6Hepatocellular Carcinoma (Hepatoma)
01/2020 - 10/2006
5Disease Progression
01/2021 - 01/2011
5Cardiovascular Diseases (Cardiovascular Disease)
01/2020 - 05/2014
5Malaria
01/2019 - 07/2014
5Hypertension (High Blood Pressure)
01/2019 - 06/2004
5Ulcerative Colitis
09/2007 - 01/2003
4Alzheimer Disease (Alzheimer's Disease)
02/2021 - 04/2010
4Stroke (Strokes)
11/2020 - 05/2010
4Hypoxia (Hypoxemia)
01/2018 - 01/2013
4Thrombosis (Thrombus)
01/2017 - 01/2010
4Neurodegenerative Diseases (Neurodegenerative Disease)
02/2014 - 02/2011
3Diarrhea
01/2022 - 05/2008
3Multiple Sclerosis
01/2022 - 10/2020
3COVID-19
06/2021 - 03/2021
3Gastroesophageal Reflux (GERD)
01/2021 - 07/2004
3Myocardial Infarction
11/2020 - 01/2018
3Liver Neoplasms (Liver Cancer)
01/2020 - 01/2012
3Fibrosis (Cirrhosis)
01/2020 - 01/2016
3Neuromyelitis Optica (Devic's Disease)
11/2018 - 03/2016
3Ischemic Stroke
01/2018 - 01/2016
3Leukemia
01/2017 - 12/2010
3Hepatitis B
01/2016 - 09/2015
3Type 2 Diabetes Mellitus (MODY)
11/2015 - 09/2008
3Non-alcoholic Fatty Liver Disease
11/2015 - 08/2013

Drug/Important Bio-Agent (IBA)

44Pharmaceutical PreparationsIBA
12/2022 - 10/2002
24TamoxifenFDA LinkGeneric
03/2022 - 11/2007
21Cytochrome P-450 CYP2D6 (CYP2D6)IBA
03/2022 - 11/2004
15Biomarkers (Surrogate Marker)IBA
01/2022 - 01/2007
15Proteins (Proteins, Gene)FDA Link
01/2022 - 10/2006
13Messenger RNA (mRNA)IBA
01/2020 - 11/2003
11Azathioprine (Imuran)FDA LinkGeneric
04/2013 - 08/2002
104-hydroxy-N-desmethyltamoxifenIBA
03/2022 - 11/2007
10EnzymesIBA
01/2022 - 05/2003
9Cytochrome P-450 CYP2C19IBA
06/2020 - 01/2002
8Estrogen ReceptorsIBA
05/2021 - 12/2008
7Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric
01/2020 - 08/2002
6Cytochrome P-450 CYP3AIBA
12/2022 - 01/2005
6Hormones (Hormone)IBA
12/2020 - 01/2008
6Fluorouracil (Carac)FDA LinkGeneric
12/2020 - 07/2007
62-mercaptopurineIBA
10/2016 - 01/2007
5Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
01/2021 - 01/2005
5Thioguanine (Tioguanine)FDA Link
01/2021 - 10/2005
5Clopidogrel (Plavix)FDA Link
06/2020 - 09/2008
5Anticonvulsants (Antiepileptic Drugs)IBA
01/2020 - 04/2014
5Phosphotransferases (Kinase)IBA
01/2020 - 06/2005
5RNA (Ribonucleic Acid)IBA
12/2019 - 04/2009
5DNA (Deoxyribonucleic Acid)IBA
01/2018 - 10/2009
5Metformin (Glucophage)FDA LinkGeneric
11/2015 - 01/2013
5Member 1 Subfamily B ATP Binding Cassette TransporterIBA
12/2014 - 07/2002
5Mesalamine (Mesalazine)FDA LinkGeneric
03/2013 - 01/2005
5thiopurine methyltransferase (thiopurine S-methyltransferase)IBA
08/2009 - 08/2002
4Tyrosine Kinase InhibitorsIBA
01/2022 - 12/2014
4Methotrexate (Mexate)FDA LinkGeneric
01/2021 - 10/2005
4Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2020 - 04/2002
4GlucocorticoidsIBA
11/2018 - 06/2005
4Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2018 - 01/2013
4C-Reactive ProteinIBA
10/2015 - 01/2011
4Adrenal Cortex Hormones (Corticosteroids)IBA
01/2011 - 09/2004
3Pregnane X ReceptorIBA
12/2022 - 01/2011
3Oxaliplatin (Eloxatin)FDA LinkGeneric
02/2022 - 09/2015
3Lactic Acid (Lactate)FDA LinkGeneric
01/2022 - 09/2013
3Glucose (Dextrose)FDA LinkGeneric
01/2022 - 07/2013
3Infliximab (Remicade)FDA Link
08/2021 - 01/2007
3Amyloid beta-PeptidesIBA
02/2021 - 12/2017
3Angiotensin Receptor AntagonistsIBA
02/2021 - 04/2010
3AcidsIBA
01/2021 - 01/2009
3Protein Isoforms (Isoforms)IBA
01/2021 - 01/2015
3Interleukin-10 (Interleukin 10)IBA
01/2021 - 04/2010
3Progesterone Receptors (Progesterone Receptor)IBA
12/2020 - 08/2006
3Formaldehyde (Formol)FDA Link
10/2020 - 12/2010
3ParaffinIBA
10/2020 - 12/2010
3LipidsIBA
10/2020 - 01/2018
3GadoliniumIBA
09/2020 - 01/2016
3Peptides (Polypeptides)IBA
01/2020 - 01/2011
3Adenosine Triphosphate (ATP)IBA
01/2020 - 01/2012
3Doxorubicin (Adriamycin)FDA LinkGeneric
01/2020 - 01/2007
3MicroRNAs (MicroRNA)IBA
01/2018 - 06/2015
3NucleotidesIBA
04/2016 - 02/2007
3myrcludex-BIBA
01/2016 - 09/2015
3CationsIBA
12/2014 - 10/2009
3DefensinsIBA
09/2014 - 09/2006

Therapy/Procedure

48Therapeutics
12/2022 - 08/2002
13Drug Therapy (Chemotherapy)
12/2022 - 09/2004
5Precision Medicine
06/2022 - 01/2015
4Percutaneous Coronary Intervention
11/2020 - 01/2010
4Aftercare (After-Treatment)
01/2013 - 03/2005